Phenotype Discovery Made Easy

Description: Many human diseases are caused by mutations in the genome. Recent advancements in DNA sequencing have identified massive amounts of rare alleles that appear to be clinically associated with a disease. Yet, definitive proof of pathogenicity remains unknown. RediMODEL is a novel way to determine if mutations in important genes cause disease. Using humanized C. elegans as a model system, we can insert individual mutations to determine if they cause disease by employing easy to use phenotypic assays. Further, any identified mutations that cause disease can be used for compound screening to find molecules that can return native function to the protein defects.

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RediMODEL Kits - 3 types of C. elegans animal models engineered for human disease discovery.

Kit Choice:

  • gene knock-out - disease gene homolog removed.
  • humanized wt gene - humanized worm containing disease gene.
  • clinical variant allele - genetic difference suspected of pathogenicity.

Fast - Ready to use in 2 days.

Easy - Clear protocols of activity.

Precise - Quantifiable phenotypes.

Accurate - Disease-relevant biology.

Simple - C. elgans experience not required.

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