RediMODEL transgenics in C. elegans
XXXX - XXXXXX
- Function: XXXX is xxxxx.
- Disease: Genetic defects in XXXX have been found to be highly associated with YYYYY.
RediMODEL kits - A series of humanized animal models specifically engineered for easy measurement of phenotype defects caused by clinically-relevant disease mutations.
XXXXX RediMODEL KO: Generated in the C. elegans homolog xxxxx as a yyyy-deletion allele leading to over zzzzz-deletion in coding sequence. The xxxx deletion knock-out (KO) results in loss of function in YYYY. Major phenotype readout for KO line is the observation of YYYYY. An all-coding deletion mutant is currently available as gene knock-out.
XXXXXX RediMODEL KI: Generated in the C. elegans homolog xxxxxx with human gene insertion to create a knock-in (KI) strain. Entire coding of xxxxx is replaced with wild-type XXXXXXX coding sequence. A XXXXX gene replacement is xxxxxxxx-currently available as a humanized wt line.
XXXXXX RediMODEL CV: Generated in the C. elegans homolog xxxxx with human gene insertion containing a clinical variant allele to create a clinical variant (CV) strain. Entire coding of xxxxx is replaced with XXXX coding sequence containing an amino-acid change polymorphism that has been observed in patient populations. Upon request, a XXXXX line with client-specific polymorphism is made as a clinical variant allele.